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Titlebook: Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5; Kenneth V. Honn,Lawrence J. Marnett,Charles Serha

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Functional coupling between Phospholipase a2s and cyclooxygenases in immediate and delayed prostanoours in parallel with the induction of COX-2 expression.l-4 However, whether distinct PLA2s are utilized selectively in the different PG-biosynthetic phases and couple specifically with each COX isozyme is controversial.
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Cyclooxygenase-2 Expression and Activity are Induced by Amyloid-Beta 1-42 in Brain-Derived Cells,enesis, however, the mechanisms of its actions are highly debatable. Recent evidence suggests that inflammation may be the pathogenetic link between AP deposition and neuronal death (Halliday et al., 2000).
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,Endothelial COX-2 induction by hypoxia liberates 6-keto-PGF1α, a potent epithelial Secretagogue,l cells are able to coordinate compositional changes of the luminal compartment. A number of stimuli, including hormones, neurotransmitters and cytokines have been shown to directly regulate epithelial function.
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Towards a Broader Definition of Development,ediators of inflammatory and anaphylactic diseases (Drazen et al., 1999). Mammalian 15-LOXs have been implicated in PPARy-mediated cell signaling (Huang et al., 1999), in cell development and maturation (Rapoport et al., 1990; van Leyen et al., 1998) as well as in the pathogenesis of atherosclerosis (Cyrus et al., 1999).
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