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Titlebook: Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury; Proceedings of the 1 Kenneth V. Honn,Lawrence J. Marnett,Thomas L. W

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Fatty Acid-Induced Modulation of Carcinogenesis in Human and Mouse Mammary Explant Culturesy 25% of women developing breast cancer present identifiable risk factors (2). Thus, in majority of women the causative factor(s), and therefore relative risk for developing breast cancer remains unknown.
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Radiation Protection and Cancer Therapy by Linoleatetected mouse bone marrow cells against radiation damage even when injected an hour or more after exposure of the mice to gamma rays (2). It seems likely, therefore, that combined radiation and LA therapy may be useful for the control of selected cancers. We have begun an investigation of the combine
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Developing Christian Servant LeadershipDifferent studies have shown, that human tumors are able to synthesize prostanoids (1–3) with significant increases in production during tumor development (4,5). An influence of cyclooxygenase metabolites of arachidonic acid on processes such as cell proliferation, migration, adherence, and hemostatic mechanisms were suggested.
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Bob Lumley,Michael O’ShaughnesseyRecently, we reported formation of lipoxins from endogenous substrate, via platelet-dependent lipoxygenation of granulocyte-derived leukotriene (LT)A. (1). Furthermore, human platelet suspensions transformed synthetic LTA. to lipoxins. The platelets also efficiently converted LTA. to cysteinyl-containing leukotrienes (2).
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The Occurence of Thromboxane Synthase in Tumor CellsDifferent studies have shown, that human tumors are able to synthesize prostanoids (1–3) with significant increases in production during tumor development (4,5). An influence of cyclooxygenase metabolites of arachidonic acid on processes such as cell proliferation, migration, adherence, and hemostatic mechanisms were suggested.
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Deficient Lipoxin Formation in Chronic Myelogenous LeukemiaRecently, we reported formation of lipoxins from endogenous substrate, via platelet-dependent lipoxygenation of granulocyte-derived leukotriene (LT)A. (1). Furthermore, human platelet suspensions transformed synthetic LTA. to lipoxins. The platelets also efficiently converted LTA. to cysteinyl-containing leukotrienes (2).
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https://doi.org/10.1007/978-1-4615-3874-5Tumor; carcinogenesis; cell; cellular differentiation; leukemia; melanoma; mutagen; ovarian cancer; preventi
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