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Titlebook: Effectors of Thermogenesis; Proceedings of a Sym L. Girardier,J. Seydoux Conference proceedings 1978 Springer Basel AG 1978 adaptation.cell

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Plasma Membrane Involvement in Brown Fat Thermogenesis Although activation of either receptor leads to brown fat thermogenesis via pathways that have some, but not all, events in common, the β-induced calorigenesis appears quantitatively greater than that elicited by the α-pathway. The sensitivity of the adrenergic-evoked respiration to Na./K. pump blo
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Does Cytoplasmic Alkalinization Trigger Mitochondrial Energy Dissipation in the Brown Adipocyte? acid-base perturbations. Specific blockage of active Na-K transport by ouabain inhibited the thermogenic response only in acidosis and more efficiently when the glycoside was administered before the catecholamine stimulus than when it was added after the full calorigenic response had developed. It
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The “Second Messenger” System in Brown Adipose Tissue of Developing Rats. Its Molecular Composition te with its final subcellular effect are summarized here. The hormone-mediated regulatory pathway consists of the adenyl cyclase and the protein kinase systems; the former is composed of the receptor and catalytic sites, the latter of regulatory and catalytic subunits. Emphasis is given currently to
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The Identification of the Component in the Inner Membrane of Brown Adipose Tissue Mitochondria Respoind to a component on the outer face of the inner membrane. This unique mechanism has been proposed to represent the molecular site of non-shivering thermogenesis in this tissue. Using a photo-affinity analogue of ATP, we have identified the nucleotide binding component as a protein of 32,000 dalton
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Polyamine and Magnesium Effects on Mitochondrial Respiration in Control and Heat-Acclimated Ratss suppress S. and S. of αKGO at 0.6–1.17 mM Mg.: some combinations of it and Mg. increase the respiratory control ratio (RCR). Spermine suppresses S. of αKGO and increases the RCR but suppresses the RCR of SO at high levels. In heat-acclimated (HA) animals in which we have studied only spermine effe
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