| 书目名称 | EBNA1 and Epstein-Barr Virus Associated Tumours |
| 编辑 | Lori Frappier |
| 视频video | |
| 概述 | Provide a comprehensive account of all EBNA1 functions and cellular effects.Discusses mechanistic basis of these EBNA1 functions and effects.Gives a balanced perspective by offering the most current e |
| 丛书名称 | SpringerBriefs in Cancer Research |
| 图书封面 |  |
| 描述 | This SpringerBrief is comprehensive account of the functions and effects of the Epstein-Barr virus (EBV) EBNA1 protein that relate to EBV-associated cancers and evidence for EBNA1 contributions to these cancers. EBNA1 was the first EBV protein detected and the most critical for EBV latent infection. EBNA1 fulfills multiple functions at EBV genomes which have been described in many (sometimes confusing) reports over the last 28 years. While these were initially thought to be the only roles of EBNA1, many reports in recent years have shown that EBNA1 also directly affects cellular processes in ways that would be expected to contribute to oncogenesis. However, the degree to which EBNA1 promotes cell survival and oncogenesis in various types of human tumours is not entirely clear and a matter of debate. This book offers a current synopsis of EBNA1 functions in EBV latency, including functions in DNA replication, mitotic segregation and transcription. Mechanisms of these EBNA1 functions is also discussed as well as implications for tumourigenesis. In addition, the cellular effects of EBNA1 will be reviewed, including how EBNA1 manipulates specific cellular proteins and relationships t |
| 出版日期 | Book 2013 |
| 关键词 | Burkitt‘s lymphoma; EBNA1; PML; USP7; gastric carcinoma; nasopharyngeal carcinoma |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4614-6886-8 |
| isbn_softcover | 978-1-4614-6885-1 |
| isbn_ebook | 978-1-4614-6886-8Series ISSN 2194-1173 Series E-ISSN 2194-1181 |
| issn_series | 2194-1173 |
| copyright | The Author(s) 2013 |
发表于 2025-3-21 20:09:45
