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Titlebook: Drugs and the Elderly; Perspectives in Geri J. Crooks,I. H. Stevenson Book 1979 J. Crooks and I. H. Stevenson 1979 absorption.analgesics.an

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楼主: Retina
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Praeludium: eine Positionsbestimmung,atisfactory, since the study designs have not allowed adequate kinetic analysis of the results obtained. A further criticism of much of the work is that individual pharmaco­kinetic parameters have been measured in isolation, and complete data on the effect of ageing on all the main pharmacokinetic processes are available for only a few drugs.
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Drug distribution in the elderly the early 1950s (for review, see Brodie, 1964) and later by Bender (1969). More recently, Klotz (1976) has emphasised that ‘distribution is a physicochemical interaction between a drug and the body’ and that ‘the pattern of this distribution is determined by the properties of the two partners’.
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Studies on drug absorption and metabolism in the elderlyatisfactory, since the study designs have not allowed adequate kinetic analysis of the results obtained. A further criticism of much of the work is that individual pharmaco­kinetic parameters have been measured in isolation, and complete data on the effect of ageing on all the main pharmacokinetic processes are available for only a few drugs.
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https://doi.org/10.37307/b.978-3-503-19584-8 the early 1950s (for review, see Brodie, 1964) and later by Bender (1969). More recently, Klotz (1976) has emphasised that ‘distribution is a physicochemical interaction between a drug and the body’ and that ‘the pattern of this distribution is determined by the properties of the two partners’.
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https://doi.org/10.1007/978-1-4471-1921-0cases. Treatment with a tricyclic antidepressant drug (e.g. amitriptyline, imipramine, nortriptyline) is the usual therapeutic approach. However, many patients fail to show a satisfactory response and there is a high frequency of adverse effects—postural hypotension, confusional states and cardiotoxicity being of particular concern.
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