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Titlebook: Drugs and Immune Responsiveness; Book 1979

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New developments in drugs enhancing the immune response: activation of lymphocytes and accessory ceects in different ways. On the one hand, they may enhance non-specific effector mechanisms operative in the resistance of infectious agents and to neoplastic cells. On the other hand, they may non-specifically increase specific immune responses elicited by the recognition of antigenic determinants.
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Drugs as haptens,ergic drug-induced rèactions either during therapy or in circumstances of occupational exposure to the drug. The majority of adverse reactions to drugs are not immunologically mediated but can be understood on the basis of direct toxicity owing to overdosage, to side effects and to secondary effects
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Adverse reactions to practolol,e syndrome in a few patients receiving the drug (Assem and Banks, 1973; Raftery and Denman, 1973). During 1974 a hitherto undescribed adverse reaction complex was discerned (Nicholls, 1976). The main features of this rare syndrome are skin rashes (Felix .. 1974), ocular involvement (Wright, 1975) an
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Approaches to prevention and treatment of drug allergy,10 to 15 per cent untoward reactions of hospitalised patients to one or the other drug administered to them; among these 40 to 50 per cent are felt to be of allergic nature (Klein .., 1972), which leaves us with an overall incidence of about 5 per cent of allergic reactions to drugs in a population
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Enzymoimmunoassays and related analytical techniques for drugs,wide applicability. Thus it is not surprising that, since the development of the first RIA for a drug, digitoxin (Smith .. 1969), such assays have been introduced for over 60 drugs (Landon and Moffat, 1976), and have proved of great value to the clinical pharmacologist and clinician. Nonetheless, RI
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