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Titlebook: Druggable Lipid Signaling Pathways; Yasuyuki Kihara Book 2020 Springer Nature Switzerland AG 2020 lipids.GPCR.drug discovery.disease.trans

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Biosynthetic Enzymes of Membrane Glycerophospholipid Diversity as Therapeutic Targets for Drug Deves. Essential physiological functions for LPLATs have been revealed in studies using gene-deficient mice, and important roles for several enzymes are also indicated in human diseases where their mutation or dysregulation causes or contributes to the pathological condition. Now several LPLATs are emer
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Druggable Prostanoid Pathway,fully designed to spare gastrointestinal toxicity, but predisposed patients to increased cardiovascular risks. These health complications from NSAIDs prompted interest in the downstream effectors of the COX enzymes as novel drug targets. This chapter describes various safety issues with tNSAIDs and
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Targeting Leukotrienes as a Therapeutic Strategy to Prevent Comorbidities Associated with Metabolic LT production and/or actions could represent an exciting new strategy to prevent or treat inflammatory diseases associated with metabolic disorders. This review is intended to shed light on the synthesis and actions of leukotrienes, the most common drugs used in clinical trials, and discuss the the
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