Titlebook: Drug Transporters in Drug Disposition, Effects and Toxicity; Xiaodong Liu,Guoyu Pan Book 2019 Springer Nature Singapore Pte Ltd. 2019 ATP

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Pls Record Book Bid Lot 49 Stop J Derrida,d PEPTs are responsible for the uptake of di-/tripeptides and peptide-like drugs. MATEs are responsible for efflux of organic cations. These transporters also transport some endogenous substances, indicating that the dysfunction of SLCs not only disrupts homeostasis but also largely impacts on the d

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Conclusions: Changing Organisationsssification system (BDDCS) put forward by Wu and Benet may help us better predict the effect of transporters on drug absorption. The drug-induced toxicity in the intestine, which may result from drug-drug interaction, gut microbiota, and bile salt toxicity, is also discussed.

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The Emergence of Large-Scale Organisationsng tight junction proteins or altering expression and function of these transporters. This chapter will illustrate function of BBB, expression of transporters, as well as their alterations under disease status.

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The Emergence of Large-Scale Organisationsmia-reperfusion) impair BRB function via altering tight junctions, RCEC death, and transporter expression. This chapter will illustrate function of BRB, expressions and functions of these transporters, and their clinical significances.

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