| 书目名称 | Drug Transporters in Drug Disposition, Effects and Toxicity | | 编辑 | Xiaodong Liu,Guoyu Pan | | 视频video | | | 概述 | Focusing on the roles of drug transporters in drug disposition, effects and toxicity.Introducing the cutting-edge developments in the study of drug transporters.Discussing the function and clinical si | | 丛书名称 | Advances in Experimental Medicine and Biology | | 图书封面 |  | | 描述 | .This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presentsa number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and pr | | 出版日期 | Book 2019 | | 关键词 | ATP binding cassette transporters; Solute carrier transporters; Drug-drug interaction; Blood-tissue bar | | 版次 | 1 | | doi | https://doi.org/10.1007/978-981-13-7647-4 | | isbn_softcover | 978-981-13-7649-8 | | isbn_ebook | 978-981-13-7647-4Series ISSN 0065-2598 Series E-ISSN 2214-8019 | | issn_series | 0065-2598 | | copyright | Springer Nature Singapore Pte Ltd. 2019 |
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书目名称Drug Transporters in Drug Disposition, Effects and Toxicity影响因子(影响力)
书目名称Drug Transporters in Drug Disposition, Effects and Toxicity影响因子(影响力)学科排名
书目名称Drug Transporters in Drug Disposition, Effects and Toxicity网络公开度
书目名称Drug Transporters in Drug Disposition, Effects and Toxicity网络公开度学科排名
书目名称Drug Transporters in Drug Disposition, Effects and Toxicity被引频次
书目名称Drug Transporters in Drug Disposition, Effects and Toxicity被引频次学科排名
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书目名称Drug Transporters in Drug Disposition, Effects and Toxicity读者反馈
书目名称Drug Transporters in Drug Disposition, Effects and Toxicity读者反馈学科排名
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发表于 2025-3-21 20:08:33
