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Titlebook: Drug Toxicity in Embryonic Development II; Advances in Understa Robert J. Kavlock (Director),George P. Daston Book 1997 Springer-Verlag Ber

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书目名称Drug Toxicity in Embryonic Development II
副标题Advances in Understa
编辑Robert J. Kavlock (Director),George P. Daston
视频video
丛书名称Handbook of Experimental Pharmacology
图书封面Titlebook: Drug Toxicity in Embryonic Development II; Advances in Understa Robert J. Kavlock (Director),George P. Daston Book 1997 Springer-Verlag Ber
描述Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world‘s literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that experimental toxicologists and molecular biologists will begin to better appreciate each others quest
出版日期Book 1997
关键词Geburtsschaden; Morphogenese; abnormal development; birth; birth defects; drug; drugs; embryo; morphogenesis
版次1
doihttps://doi.org/10.1007/978-3-642-60447-8
isbn_softcover978-3-642-64409-2
isbn_ebook978-3-642-60447-8Series ISSN 0171-2004 Series E-ISSN 1865-0325
issn_series 0171-2004
copyrightSpringer-Verlag Berlin Heidelberg 1997
The information of publication is updating

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Retinoidsin organogenesis at several stages and sites during normal embryonic development. The offspring of female rats fed vitamin A-deficient diets prior to and during gestation show numerous malformations in the eyes, the genitourinary system, the diaphragm, and, less frequently, the heart (W. and W. 1950
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Alcohols: Ethanol and Methanols of metabolismwhich must be considered when evaluating putative mechanisms by which these alcohols might produce dysmorphogenesisfollowing maternal exposure; aspects of the pharmacokinetics of ethanol and methanol relevant to evaluatinganimal models and mechanisms of action are presented. In this a
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Developmental Toxicity of Dioxin: Searching for the Cellular and Molecular Basis of Morphological Re. Prenatal exposure to TCDD adversely affects other developing systems, including the urogenital tract and the immune system, and a brief discussion of these topics will be presented. Reviews of reproductive and immunological responses are available in P. et al. (1993) and H. and L. (1994).
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