书目名称 | Drug Safety Evaluation | 副标题 | Methods and Protocol | 编辑 | Jean-Charles Gautier | 视频video | | 概述 | Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts | 丛书名称 | Methods in Molecular Biology | 图书封面 |  | 描述 | .This second edition provides up-to-date chapters and new chapters focusing on the most recent advances in the field of drug safety evaluation. Divided into seven parts, chapters detail specific aspects related to the experimental design of preclinical studies conducted to support the safety of pediatric and combination drugs, necropsy and histopathology evaluation, mass spectrometry imaging, genetic toxicology protocols including the .Pig-a. mutation assay, safety pharmacology methods such as automatization of patch-clamp procedures, target safety assessment for investigative toxicology, screening assays for developmental toxicology, and methods to characterize novel translational safety biomarkers like microRNAs. Written in the highly successful .Methods in Molecular Biology .series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting to avoid known pitfalls..Authoritative and practical,. Drug Safety Evaluation: Methods and Protocols, Second Edition. aims to ensure successful results in the further study of this vital field.. | 出版日期 | Book 2017Latest edition | 关键词 | immunohistochemistry; mass spectrometry imaging; histopathology evaluation; Pig-a mutation; patch-clamp | 版次 | 2 | doi | https://doi.org/10.1007/978-1-4939-7172-5 | isbn_softcover | 978-1-4939-8406-0 | isbn_ebook | 978-1-4939-7172-5Series ISSN 1064-3745 Series E-ISSN 1940-6029 | issn_series | 1064-3745 | copyright | Springer Science+Business Media LLC 2017 |
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