Titlebook: Drug Discovery in Africa; Impacts of Genomics, Kelly Chibale,Mike Davies-Coleman,Collen Masimirem Book 2012 Springer-Verlag Berlin Heidelbe

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Innovative Approaches to Exploiting Traditional Medicines in Malaria,ies, especially those living in remote areas, rely on traditional medicine to treat the disease. Our research on ethnobotany-based malaria chemotherapy began in the 1990s following the sudden resurgence of the disease. Our work was first focused on drugs that could reverse chloroquine resistance in

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Anticancer Drug Repositioning Against Tropical Diseases: The Example of Methotrexate in the Treatmerged in South East Asia, and experience indicates that this resistance would eventually reach Africa, a scenario that would be associated with increased malaria morbidity and mortality. Thus, more than ever, new drugs are urgently needed. One of the strategies to discover new drugs is to reposition

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Random and Rational Approaches to HIV Drug Discovery in Africa,he virus as the causative agent of the acquired immune deficiency syndrome (AIDS). Within a short period of time thereafter, azidothymidine (AZT) was found to inhibit viral replication and became the first FDA-approved drug for the treatment of HIV/AIDS in 1987. Since then, continual and substantial

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Structure-Based Design of Domain-Selective Angiotensin-Converting Enzyme Inhibitors,ve control of this disease. Angiotensin-converting enzyme (ACE) is a two-domain zinc metallopeptidase that plays a central role in the renin-angiotensin-aldosterone system and has thus been identified as a promising therapeutic target in the treatment of CVD and its major risk factor, hypertension.

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Natural Products and Antimalarial Drugs: Will Africa Provide the Next Major Breakthrough?,umerous plants that are reputed to have various medicinal properties, to date, not a single compound has been discovered in any African plant that has made it to clinical application in malaria chemotherapy. But Africa has the greatest malaria burden in the world. This chapter discusses previous and

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Nanomedicine in the Development of Drugs for Poverty-Related Diseases,d bioavailability and thus reduced efficacy. In addition, there is lack of activity from the pharmaceutical industry due to the difficulty in refinancing the high development costs. Hence, new approaches have to be explored for the treatment of PRDs. Nanotechnology-based drug delivery systems (nanom

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rtunities, as well as a collection of strategies and techniq.Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research a

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Toshiyuki Moriuchi,Toshikazu Hiraoesiding off the more accessible southern African coast. A total of 18 South African marine natural products have been patented for their anti-cancer activity with the marine tube worm metabolite cephalostatin 1 and a synthetic analogue of the sponge metabolite hemiasterlin, showing the greatest promise for new drug development.