| 书目名称 | Drug Delivery to the Brain |
| 副标题 | Physiological Concep |
| 编辑 | Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lan |
| 视频video | |
| 概述 | Describes small and large drug delivery to the brain with emphasis on the physiology and concepts for drug delivery across the BBB and brain distribution.Contains methods for studying drug delivery, r |
| 丛书名称 | AAPS Advances in the Pharmaceutical Sciences Series |
| 图书封面 |  |
| 描述 | The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes an |
| 出版日期 | Book 20141st edition |
| 关键词 | blood-brain barrier; drug delivery blood-brain barrier; transporters |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4614-9105-7 |
| isbn_softcover | 978-1-4939-4366-1 |
| isbn_ebook | 978-1-4614-9105-7Series ISSN 2210-7371 Series E-ISSN 2210-738X |
| issn_series | 2210-7371 |
| copyright | American Association of Pharmaceutical Scientists 2014 |
发表于 2025-3-21 19:46:27
