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Titlebook: Drug Action at the Molecular Level; G. C. K. Roberts Book 1977 Institute of Biology Endowment Trust Fund 1977 drug.research.Symposium

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Substrate and inhibitor binding to dihydrofolate reductase,olate, plays a vital role in intermediary metabolism, acting as a ‘carrier’ of one-carbon fragments in the biosynthesis of a number of amino acids, thymidylate and purines (for a review, see Blakley, 1969).
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,Interaction of ouabain and cassaine with Na+ + K+ — ATPase and its relationship to their inotropic ng its transport cycle, access to both sides of the cell membrane (Post .. 1969). The transport function of Na. + K. — ATPase is required for volume control in the cell, but it also subserves many other cellular functions (Post, 1968).
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Indikation und Behandlungssettingthat aromatic and heterocyclic sulphonamides with unsubstituted R—SO. NH. groups constitute a class of powerful inhibitors, while aliphatic sulphonamides are poor inhibitors of the carbonic anhydrases.
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Strukturierung des Therapieablaufsbviously a . for understanding these events is a fairly detailed knowledge of the nature of the receptor and its conformation in the unperturbed state. Needless to say, the receptor is generally reckoned to be a macromolecule of some sort — quite likely (but not necessarily) a protein.
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Wolfgang Krueger,Bernd Froehlich particular accessibility of this site to electrophysiological and pharmacological analysis. The underlying molecular determinants of the synaptic activity have not, however, yet been defined. The molecular biology of the functioning cholinergic synapse is still at an early stage.
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