Titlebook: Drug Action at the Molecular Level; G. C. K. Roberts Book 1977 Institute of Biology Endowment Trust Fund 1977 drug.research.Symposium

无弹性

The molecular basis for the inhibitory action of 6-(arylhydrazino)-pyrimidines on the replication-slazo)pyrimidines were conceived and synthesised by Bernard Langley of Imperial Chemical Industries, Ltd in the early 1960s. Langley and his colleagues, in their initial studies of biological activity of the arylazopyrimidines, observed that they were potent inhibitors of the growth of Gram-positive

palliative-care

虚构的东西

自恋

The mechanism of cytochrome P450-catalysed drug oxidations,riety of metabolic reactions. Lipophilic molecules, like steroids or the fat-soluble vitamins, are in the minority. These latter compounds consist, in substantial part, of aromatic or alicyclic rings and/or aliphatic side-chains. These hydrocarbon groups are metabolically rather inert and in fact on

混合

,Interaction of ouabain and cassaine with Na+ + K+ — ATPase and its relationship to their inotropic identical with, the sodium pump activity of cell membranes. ., this enzyme pumps sodium out of and potassium into the cell and it has therefore, during its transport cycle, access to both sides of the cell membrane (Post .. 1969). The transport function of Na. + K. — ATPase is required for volume c

公猪

Adenylate cyclase: actions and interactions of regulatory ligands,shed by Sutherland and his associates (Sutherland and Rall, 1960) that the only ingredients necessary to elicit a hormonal effect on the enzyme were magnesium ion, ATP, hormone and membranes bearing the enzyme. This seemingly simple system, in which hormone was shown to increase the . of adenylate c

健忘症

Properties and function of the acetylcholine receptor of vertebrate skeletal muscle,al synapse. An impressive history of electrophysiological and pharmaco-logical investigation has revealed the outline of the events involved in transmission there (Katz, 1966; Hubbard, 1974; Rang, 1974). The quantal release of ACh,* the activation of receptors by the transmitter, the depolarisation

Optimum

https://doi.org/10.1007/978-1-349-03230-3drug; research; Symposium

异教徒

thwart

Analyse der Kooperation und ComplianceWhat would the molecular pharmacologist really like to know? It may seem arrogant for a theoretician to pose and attempt to answer this question, but it is necessary if the full value of theoretical calculations is to be appreciated.