Titlebook: Drug Absorption Studies; In Situ, In Vitro an Carsten Ehrhardt,Kwang-Jin Kim Book 2008 Springer-Verlag US 2008 Assessment.Expression.Transp

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eustachian-tube

Instrumented In Vitro Approaches to Assess Epithelial Permeability of Drugs from Pharmaceutical Formth epithelial cell cultures in vitro. The first section is focused on the combined assessment of drug release/dissolution and subsequent absorption/permeation for solid oral dosage forms. Experimental approaches to mimic the complex physiologically surroundings in the gastrointestinal tract are pres

Organization

Claudia Müller,Marén Schorch,David Struzekskin sensitization, skin irritation and corrosion, and skin phototoxicity testing. Altogether an up-to-date status on techniques concerning skin invasion testing and skin toxicity testing is provided.

暂时别动

Reinventing the Wheel of Media Theoryble and the issues associated with choice of animal tissue used in preclinical drug absorption studies. Most of our work in this field has been performed using porcine buccal mucosa in modified Ussing chambers, and the reader is referred to the appendix (available online) for a comprehensive protocol on this technique.

镇压

Clemens Eisenmann,Kathrin Englert,Ehler Vossitro nasal drug transport and metabolism studies are based on animal tissues. A comparative treatise of various in situ and ex vivo nasal models is presented in this chapter. The advantages, limitations, specific applications of the various models in preclinical drug development, and in vivo/in vitro correlations are highlighted.

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Horizon

Models for Skin Absorption and Skin Toxicity Testingskin sensitization, skin irritation and corrosion, and skin phototoxicity testing. Altogether an up-to-date status on techniques concerning skin invasion testing and skin toxicity testing is provided.

Debate

In Vivo and In Vitro Models for Assessing Drug Absorption Across the Buccal Mucosable and the issues associated with choice of animal tissue used in preclinical drug absorption studies. Most of our work in this field has been performed using porcine buccal mucosa in modified Ussing chambers, and the reader is referred to the appendix (available online) for a comprehensive protocol on this technique.

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Regulation of Paracellular Permeability in Low-Resistance Human Vaginal-Cervical Epitheliaeformability and the .LIS. The knowledge gained from these studies on the molecular mechanisms involved may improve the understanding of dysregulation of water and solutes, and related diseases. The data may be also used in future clinical trials to improve topical drug delivery via the vaginal route in women.