| 书目名称 | Drug Absorption Studies | | 副标题 | In Situ, In Vitro an | | 编辑 | Carsten Ehrhardt,Kwang-Jin Kim | | 视频video | | | 概述 | Comprehensively summarises the different approaches to assess drug absorption from in vitro models.Gives a review on the current state-of-the-art in pharmaceutical cell biology.Provides readers with h | | 丛书名称 | Biotechnology: Pharmaceutical Aspects | | 图书封面 |  | | 描述 | .In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These .in vitro. models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex .in vivo. situation, .in vitro. models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening....Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary .in vitro. techniques for drug absorption studies. In addition, chapters on high-throughput assays, .in vitro.-.in vivo. correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of avail | | 出版日期 | Book 2008 | | 关键词 | Assessment; Expression; Transport; bioinformatics; biotechnology; cell biology; cell lines; cloning; medicin | | 版次 | 1 | | doi | https://doi.org/10.1007/978-0-387-74901-3 | | isbn_softcover | 978-1-4899-7754-0 | | isbn_ebook | 978-0-387-74901-3 | | copyright | Springer-Verlag US 2008 |
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发表于 2025-3-21 16:57:55
