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Titlebook: Dopamine in the Gut; Jin-Xia Zhu Book 2021 Springer Nature Singapore Pte Ltd. 2021 Dopamine.dopamine receptor.brain-gut axis.gastrointesti

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Introduction,r energy, growth, and repair. Functions of the digestive system are controlled by the autonomic nervous system, gastrointestinal hormones, local paracrine messengers, immune factors, and microbiota in the gut. Dopamine is a type of catecholamine that is found not only in the brain but also in the gu
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Synthesis and Metabolism of Gut Dopamine,d pancreas. Additionally, colonic lumen also contains substantial DA. The rapid degradation of DA ensures its proper function in various locations in the body. Monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT) are the main metabolic enzymes of DA and are widely distributed in the gut.
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Introduction,nts with Parkinson’s disease (PD). Paradoxically, enzymes for dopamine synthesis and dopamine transporter levels are higher in the gut of PD animal models. Patients with PD often have impairment in gastrointestinal function such as gastroparesis or constipation, which usually appears many years befo
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