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Titlebook: Dopamine Receptor Agonists; George Poste,Stanley T. Crooke Book 1984 Springer Science+Business Media New York 1984 cardiovascular system.d

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书目名称Dopamine Receptor Agonists
编辑George Poste,Stanley T. Crooke
视频video
丛书名称New Horizons in Therapeutics
图书封面Titlebook: Dopamine Receptor Agonists;  George Poste,Stanley T. Crooke Book 1984 Springer Science+Business Media New York 1984 cardiovascular system.d
描述Dopamine, in addition to its importance as a precursor of norepinephrine, is now known to be an important neurotransmitter in regulating functional activities in a number of major organ systems, including the central ner­ vous system. the cardiovascular system, the kidney, and the gut. Recent advances in our understanding of the functional role of dopamine, its mechanism of action and the pharmacology of dopaminergic agents have occurred on a broad front. The last few years have witnessed significant progress in the identification and classification of central and peripheral dopamine receptors and the factors that affect their responsiveness to inhibitory and stimulatory ligands. These advances have been paralleled by new insights into the contribution of alterations in dopaminergic reg­ ulation in causing disease and the utility of dopamine agonists and an­ tagonists as therapeutic modalities. This volume, the first in a series of publications arising from the annual Smith Kline and French Research Symposium on New Horizons in Therapeutics, provides a comprehensive survey of current research on peripheral dopamine receptors and the physiologic and therapeutic con­ sequences of sti
出版日期Book 1984
关键词cardiovascular system; dopamine; drug; kidney; neurotransmitter; pharmacology; research; treatment
版次1
doihttps://doi.org/10.1007/978-1-4757-0310-8
isbn_softcover978-1-4757-0312-2
isbn_ebook978-1-4757-0310-8
copyrightSpringer Science+Business Media New York 1984
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978-1-4757-0312-2Springer Science+Business Media New York 1984
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Limitations and Future Researchhereas stimulating, mimicking or antagonizing norepinephrine and epinphrine have been the most frequently utilized approach to cardiovascular renal therapeutics, the possibility that dopamine and dopamine receptors serve as useful target sites for drug action has received less attention.
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Unternehmensstrategie - treffend verpackt66). Dopamine also may serve as a neurotransmitter in the periphery, as it inhibits prolactin secretion directly at the pituitary lactotroph and dilates the renal and mesenteric vascular beds (MacLeod, 1976; Goldberg, 1975).
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Unternehmensstrategie - treffend verpacktWe have subdivided dopamine (DA) receptors by differences in activity and potency of agonists and by demonstration of specific antagonism. The responses we have utilized can be measured in the human. Accordingly, if the subdivision is valid, the data should be useful for clinical studies.
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The Relationship of Receptor Actions of Dopamine Agonists to Their Clinical EffectsWe have subdivided dopamine (DA) receptors by differences in activity and potency of agonists and by demonstration of specific antagonism. The responses we have utilized can be measured in the human. Accordingly, if the subdivision is valid, the data should be useful for clinical studies.
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