Titlebook: Dissecting Regulatory Interactions of RNA and Protein; Combining Computatio Marvin Jens Book 2014 Springer International Publishing Switzer

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The Complete Handbook of the Internethods. In this chapter, the underlying approaches of crosslinking and immunprecipitation (CLIP) of RBP-bound RNA fragments are presented. The computational analysis and filtering of the resulting sequencing data are explained. The design and function of the computational PAR-CLIP analysis pipeline us

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Splenic Pooling and Survival of Blood Cellsith a complex, and large pool of RNA. Many RBPs (such as HuR) are described to be not themselves catalytically active with respect to the bound RNA, but to “recruit” (e.g., by protein–protein interactions) other factors, or to prevent such factors from binding. The efficacy of such indirect function

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David R. Anderson MD,John G. Kelton MDbinding of RNA-binding proteins (RBPs) and regulatory RNAs (such as miRNAs) are discussed in the light of RNA competition. The hypothesis of novel “constants of regulation,” which emerge from the composition of the transcriptome as a whole is put forward, based on the idea that the function of trans