Titlebook: Diagnostic and Therapeutic Antibodies; Andrew J. T. George,Catherine E. Urch Book 2000 Humana Press 2000

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The Antibody Moleculedies against the bacterial exotoxins (.). Around the same time, it was shown that antisera against cholera vibrios could transfer immunity to naïve animals, and also kill the bacteria in vitro (.). However, although antitoxin antibodies rapidly found clinical application, there was little understand

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Polyclonal and Monoclonal Antibodiesttractiveness of antibodies as laboratory and clinical reagents. One aspect of the body’s reaction to invasion by a microorganism is the activation and clonal expansion of antigen-reactive B lymphocytes. Once these have matured into plasma cells, each clone of cells will secrete its own unique speci

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Phage Display Technology, the method has limitations. The use of recombinant DNA technology and demonstration by Smith 1985 (.) that peptides can be expressed on the surface of filamentous bacteriophages have permitted the development of a powerful new methodology for the generation and isolation of novel antibody-based re

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Antibodies for Neoplastic Diseaseity and affinity. These reagents therefore have long held promise as a means of influencing the growth and spread of malignant disease. Over a number of decades therapeutic antibodies have been developed either as single entities or conjugated to a variety of potential disease-ameliorating agents.

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The Application of Monoclonal Antibodies in the Treatment of Lymphomacan be made with precise specificity and in almost unlimited amounts. In addition, mAbs can be selected or engineered to efficiently recruit the body’s effector systems, such as complement and natural killer cells, against the unwanted cells in much the same way as they might destroy an invading pat

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Antibody-Based Therapies in Infectious Diseasesinning of the 20th century, serum therapy had taken a place in standard treatment protocols for several infectious diseases, such as meningitis, diphtheria, tetanus, and lobar pneumonia. As early as 1906, antimeningococcal serum was intravenously used as a treatment for meningitis, since it was prov

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