| 书目名称 | Development of a New Heterocycle-Forming Reaction and Kinetic Resolution with N-Heterocyclic Carbene |
| 编辑 | Yinli Wang |
| 视频video | |
| 概述 | Nominated as an outstanding PhD thesis by Kyoto University.Provides comprehensive information on N-heterocyclic carbenes.Offers practical guidance on the design and optimization of catalytic reaction |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | .In this book, the author focuses on exploring new organocatalytic transformations under operationally simple and environmentally friendly reaction conditions. Two new types of catalytic reactions promoted by N-heterocyclic carbenes (NHCs) are described. The oxa- and azacycle-forming reactions of sulfonylalkynols and sulfonylalkynamides are broadly considered to be a new type of activation mode in NHC chemistry, wherein the bond formation with internal O- and N-nucleophiles occurs at the γ-position of the propargyl sulfones with 1,2-sulfonyl migration. The resulting oxa- and azacycles are core structures in many biologically significant compounds and medicinally important agents. .In addition, the book develops the chiral NHC-catalyzed kinetic resolution of α-hydroxy carboxylic acid derivatives based on chiral recognition of the substrate–cocatalyst complex. In this carboxylate cocatalyst-assisted chiral acylation, the reaction rate acceleration and selectivity enhancementare interpreted in terms of the reversible complexation of the substrate and carboxylate cocatalyst, which is verified by control experiments and measured using analytical methods. The findings described here reve |
| 出版日期 | Book 2019 |
| 关键词 | Chiral Recognition; N-heterocyclic Carbine; Heterocycle Formation; Kinetic Resolution; Chiral Recognitio |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-981-13-9398-3 |
| isbn_softcover | 978-981-13-9400-3 |
| isbn_ebook | 978-981-13-9398-3Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer Nature Singapore Pte Ltd. 2019 |
发表于 2025-3-21 16:24:47
