| 书目名称 | Development of In-Tether Carbon Chiral Center-Induced Helical Peptide |
| 副标题 | Methodology and Appl |
| 编辑 | Kuan Hu |
| 视频video | |
| 概述 | Nominated as an outstanding PhD thesis by Peking University.Reports on important progress in the study of stabilized peptide drugs.Introduces applications in cancer stem cell therapy and self-assembly |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | .This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs. . |
| 出版日期 | Book 2021 |
| 关键词 | Stabilized peptide; Staple peptide; Chirality; Cell permeability; Helicity; Protein-protein interactions; |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-981-33-6613-8 |
| isbn_softcover | 978-981-33-6615-2 |
| isbn_ebook | 978-981-33-6613-8Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer Nature Singapore Pte Ltd. 2021 |
发表于 2025-3-21 19:04:19
