Titlebook: Development of Antibody-Based Therapeutics; Translational Consid Mohammad A. Tabrizi,Gadi G. Bornstein,Scott L. Kla Book 2018Latest edition

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Biophysical Considerations for Development of Antibody-Based Therapeutics,n complexes for drug candidate optimization and the design of clinical dosing strategies. For measuring the dissociation equilibrium constants of monoclonal antibodies binding reversibly to antigens, two premier technologies are commonly used: Biacore surface plasmon resonance (SPR) and the solution

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Novel Technologies for Generation of Bispecific Constructs,odalities may offer additional advantages with respect to target engagement that may not be feasible by traditional combination therapies with single agents. Therefore, design of bispecific constructs requires particular attention to target and drug selection for successful application of this class

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Antibody Drug Conjugates: Translational Considerations,argeted antibodies and the high potency of small-molecule drugs with the aim of achieving durable responses in patients. As application of highly potent small-molecule drugs can be limited by their undesirable toxicity, targeted delivery of highly potent small-molecule drugs to specific cells is int

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Application of PK-PD Modeling and Simulation Approaches for Immuno-Oncology Drugs,ught about new challenges with critical relevance to the design of optimal dose and dosing regimens both as single-agent therapy and in combination with other cancer drugs. Since the first immune checkpoint inhibitor (ipilimumab) was introduced in clinical practice in 2011, there has been considerab

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risks to humans.Shows how the flow of information from lateWith a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic