Titlebook: Development of Antibody-Based Therapeutics; Translational Consid Mohammad A. Tabrizi,Gadi G. Bornstein,Scott L. Kla Book 2018Latest edition

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https://doi.org/10.1007/978-3-658-27904-2erations, underlying pharmacology and pathophysiology, as well as integration of key translational considerations can accelerate drug development processes, ultimately benefiting patients in need of such therapies. In the previous edition of this book (First Edition), translational considerations fo

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Translational Considerations and Challenges: An Overview,erations, underlying pharmacology and pathophysiology, as well as integration of key translational considerations can accelerate drug development processes, ultimately benefiting patients in need of such therapies. In the previous edition of this book (First Edition), translational considerations fo

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Considerations for Construct and Affinity Design Goals, in establishing affinity design goals. Selection of the adequate affinity for a functional biologic construct should allow achievement of the maximum therapeutic benefit at a dose associated with a manageable cost of goods. This chapter will further expand on the topics discussed previously (Develo

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Correction to: Considerations for Construct and Affinity Design Goals,

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Introduction, topics relevant for development of antibody-based therapeutics, this Second Edition will provide in-depth coverage of the key topics related to development of targeted therapeutics with key focus on the recent developments in the field. Recent advances span development of targeted modalities in exc

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Translational Considerations and Challenges: An Overview,ditions such as psoriasis and cancer. This high number of approvals followed the previous record number of approvals of ten monoclonal antibodies in 2015. Such high approval rate for biologics is a testament to advances in antibody technology and the unique advantage that this class of therapeutics

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Epitope Characterization and Isotype Selection,n molecular interactions are responsible for biological function(s) at a cellular level. The post-genomic era has witnessed the emergence of improved and state-of-the-art technologies to characterize structure-function relationships. The emergence of these technologies has been further facilitated b