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Titlebook: Development and Recognition of the Transformed Cell; Mark I. Greene,Toshiyuki Hamaoka Book 1987 Plenum Press, New York 1987 biology.cell.c

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Involvement of Human Retrovirus in Specific T-Cell Leukemia,ellular counterparts, and their significance in tumor development has been obtained from studies on retroviruses. Moreover, interest in oncogenes is now apparent in other fields of science, including developmental biology.
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Cytogenetics of Neoplasia,romosome abnormalities, which are not present in other cells of the body; (2) in a given tumor, all the neoplastic cells often have the same cytogenetic change, or related changes; (3) chromosome abnormalities are more extensive in advanced tumors; and (4) although chromosome alterations often diffe
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Oncogene Products as Receptors,rtain processes relevant to carcinogenesis. An important realization involved the recognition of the role of changes in DNA in the induction of cancer. In karyotypic studies of patients with chronic granulocytic leukemia, Nowell and Hungerford described chromosomal aberrations associated with a type
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Monoclonal Antibodies Reactive with the , Oncogene Product Inhibit the Neoplastic Properties of ,-Ts initially identified specific genes that were able to confer neoplastic properties on cells in tissue culture and that were responsible for tumor formation ... These genes were termed oncogenes. Subsequently, it was shown that genes closely related to retroviral oncogenes (protooncogenes) exist in
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Relationship of the c-, Protooncogene Product to the CSF-1 Receptor,ochemical functions of protooncogene products are elucidated, we are beginning to formulate a better understanding of the processes that govern cell proliferation and are gaining parallel insights into how aberrant stimuli for growth predispose to malignancy. The products of at least two classes of
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