Titlebook: Design and Analysis of Vaccine Studies; M. Elizabeth Halloran,Ira M. Longini,Claudio J. St Book 2010 Springer-Verlag New York 2010 Biostat

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Analysis of Households in Communities,t condition on exposure to infection. The second is a conditional parameter. The models can be formulated in discrete time or continuous time. For some data structures, such as data on sexual contacts, contacts can be substituted for time. Models formulated in discrete time have a parameter for the

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Randomization and Baseline Transmission,roups. Thus, the treatment groups are seen as comparable. Baseline transmission, pre-existing immunity, and individual responsiveness are examples of possibly relevant factors. For these reasons, randomization, in addition to double-masking, are usually proposed as good research practices for valid

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Calin Belta,Boyan Yordanov,Ebru Aydin Golterplay between individual and population level immunity is maintained through the dependent happenings..The immune response is also the source of many safety considerations of vaccination. Before a vaccine can be shown efficacious against infection or disease in a large-scale field study, it must b