Titlebook: Degenerative Retinal Diseases; Matthew M. LaVail,Joe G. Hollyfield,Robert E. Ande Book 1997 Springer Science+Business Media New York 1997

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Matthew M. LaVail,Joe G. Hollyfield,Robert E. Ande

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Subretinal Iodoacetate,space and promoted a localized IA effect. Subretinal IA dissolved in BSS caused less severe and less consistent PR degeneration. Healon® or BSS alone did not induce PR damage. Thus, a model with PR-lacking area centralis has been created by subretinal injection of IA with a viscous solution. This mo

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Hereditary Retinal Dystrophy of Swedish Briard Dogs,is and direct sequencing of PCR products to screen the coding region as well as most splice donor and acceptor sites for mutations in a small kinship of dogs consisting of six offspring of an affected Swedish Briard dog. Our analysis revealed various sequence polymorphisms in all genes except arrest

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The Vpp Mouse,r degeneration (6-9). The purpose of this chapter is to summarize a series of studies that have been carried out on one of these transgenic lines, the so-called ‘VPP’ mice (7). The available evidence indicates that the VPP mice may be a particularly useful animal model of adRP because they bear a cl

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Defective Choroidal Angiogenesis Precedes Retinal Pigment Epithelial Phagocytic Defect in Neonatal the choroidal angiogenesis defect in mutant RCS rat pups, as well as our recent evidence indicating a reduction in the mRNA and protein for basic fibroblast growth factor (bFGF) in intact RPE of neonatal RCS rats (5). This new data is discussed in the context of previous conflicting investigations