| 书目名称 | Decoding the Antibody Repertoire |
| 副标题 | High Throughput Sequ |
| 编辑 | Brandon DeKosky |
| 视频video | |
| 概述 | Nominated as an outstanding Ph.D thesis by the University of Texas at Austin.Outlines the development of the very first technology for high-throughput analysis of paired heavy and light chain antibody |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | .This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening an entirely new window for antibody discovery and the investigation of adaptive immune responses to vaccines and diseases..Previous methods for high-throughput immune repertoire sequencing have been unable to provide information on the identity of immune receptor pairs encoded by individual B or T lymphocytes. The author directly addresses these limitations by designing two new technologies for sequencing multiple mRNA transcripts from up to 10 million isolated, single cells.. .The techniques developed in this work have enabled comprehensive interrogation of human B-cell repertoires and have been applied for rapid discovery of new human antibodies, to gain new insights into the development of human antibody repertoires, and for analysis of human immune responses to vaccination and disease.. |
| 出版日期 | Book 2017 |
| 关键词 | B Cell; Single-cell Sequencing; Antibody; Immunology; Immune Repertoire; High-throughput Sequencing; Next |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-58518-5 |
| isbn_softcover | 978-3-319-86421-1 |
| isbn_ebook | 978-3-319-58518-5Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer International Publishing AG 2017 |
发表于 2025-3-21 19:22:42
