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Titlebook: Damage-Associated Molecular Patterns in Human Diseases; Volume 3: Antigen-Re Walter Gottlieb Land Book 2023 The Editor(s) (if applicable) a

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Virulence of Pathogens and the Counteracting Responses of the Hostf host defense protein levels by either transcriptional regulation or protein degradation and repurposing or inhibiting these cellular immune factors by molecular hijacking or by regulating their PTM status. On the other hand, as outlined and discussed in the second part, the development of multiple
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The Pathogenetic Role of DAMPs in Severe Infectious Diseasescus is on the pathogenetic involvement of DAMPs and SAMPs in its typical hallmarks: the cytokine storm, an immunosuppressive state, and disseminated intravascular coagulation. In sepsis, the same scenario is again highlighted: the pathogenetic implication of various subclasses of DAMPs and SAMPs in
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DAMPs in Organ-Specific Autoimmune Diseasesases in patients who are genetically predisposed to develop them. In multiple sclerosis, it is emphasized that this disease is nowadays thought to be a disorder in which DAMPs released from subroutines of regulated cell death (e.g., ferroptosis), such as HMGB1 and S100A8/9 proteins, are sensed by pa
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Approaching the DAMPome: Evolution in Medicine?in their daily struggle for survival against varmints, the Darwinian “struggle for life”: from plants to invertebrates to vertebrates: “DAMPs across the tree of life.” A typical example of such DAMP-triggered defensive responses across the tree of life is the volatile DAMP-promoted indirect defense
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