Titlebook: DNA-Encoded Chemical Libraries; Methods and Protocol David Israel,Yun Ding Book 2022 Springer Science+Business Media, LLC, part of Springer

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书目名称DNA-Encoded Chemical Libraries影响因子(影响力)




书目名称DNA-Encoded Chemical Libraries影响因子(影响力)学科排名




书目名称DNA-Encoded Chemical Libraries网络公开度




书目名称DNA-Encoded Chemical Libraries网络公开度学科排名




书目名称DNA-Encoded Chemical Libraries被引频次




书目名称DNA-Encoded Chemical Libraries被引频次学科排名




书目名称DNA-Encoded Chemical Libraries年度引用




书目名称DNA-Encoded Chemical Libraries年度引用学科排名




书目名称DNA-Encoded Chemical Libraries读者反馈




书目名称DNA-Encoded Chemical Libraries读者反馈学科排名

潜伏期

Library Synthesis: Building Block Validation,nsuring the quality of a library. Here we describe the validation method used to assess the reactivity of potential building blocks to be included in a DNA-encoded library, with HATU acylation of carboxylic acid building blocks with an on-DNA amine substrate as an example.

Congestion

Library Synthesis and Analytics,to billions of compounds can be prepared by a combination of chemical and enzymatic synthesis. Here we describe the analytics methods used in the library synthesis with one cycle of synthesis as an example.

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DNA-Compatible Nitro Reduction and Synthesis of Benzimidazoles,rary structure diversity is often limited to DNA-compatible chemical reactions in aqueous media. Herein, we describe a facile process for reducing aryl nitro groups to aryl amines by using sodium dithionite (Na.S.O.). The new protocol offers simple operation and circumvents the pyrophoric potential

cultivated

DNA Encoding of Natural Products,mbinatorial synthesis. Natural products (NPs) are evolutionary optimized compounds that have played a key role in the history of human drug discovery. Herein, we describe a method for functionality-independent annotation of complex natural products with amplifiable DNA barcodes to generate a DNA-enc

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One Bead-One Compound (OBOC) Peptidomimetic-Encoded Library Synthesis via Split-and-Pool Methods, of therapeutically important compounds with higher affinity and improved pharmacological properties against different protein targets..Here we describe a simple and general method for the submonomer solid phase synthesis of large one bead-one compound (OBOC) peptidomimetic libraries of structurally

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DNA Conjugates as Tool Compounds for DEL Selections,e ligand that binds to the target protein can be conjugated to DNA to mimic compounds contained in DEL libraries. The conjugate can be used as a ligand in preselection binding assays to validate a target protein and optimize selection methods and serve as a positive control in selection experiments.