Titlebook: DNA and Histone Methylation as Cancer Targets; Atsushi Kaneda,Yu-ichi Tsukada Book 2017 Springer International Publishing AG 2017 Demethyl

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The Molecular Basis of Histone Demethylation aspects of all seven known KDM families are reviewed as well as our present knowledge of their involvement in cancers. Control of their aberrant behavior by design of chemical inhibitors, that have the potential to be powerful cancer fighting drugs, is an expanding human endeavor and is chronicled

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Flatter

DNA Methylation and Dysregulation of miRNA in Cancerrs, including DNA methyltransferases (DNMTs), histone deacetylases (HDACs), and polycomb group genes. When this complicated feedback loop between miRNAs and epigenetics is dysregulated by aberrant expression of miRNAs, normal physiological functions are disrupted, and as a result, several diseases o

Decibel

Genomic Imprinting Syndromes and Cancer general imprinting mechanisms, representative clinical features and causative molecular alterations of eight imprinting syndromes are described. In addition, representative molecular alterations of imprinted DMRs or imprinted genes associated with tumors are also described.

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DNA and Histone Methylation in Brain Cancerng enzymatic modifications to DNA or histone proteins, thereby regulating gene expression, are increasingly recognized as a source of phenotypic variability in biology. Of epigenetic marks, DNA and histone methylation is a key mark that regulates gene expression and thus modulates a wide range of on

MINT

Liao-Chai-Chih-Iby P’u Sung-Lingf binding proteins at multiple molecular layers. Given that the disruption of histone methylation and recognition has been associated with altered gene function in various diseases and human malignancy, understanding the regulation of histone methylation and recognition will also provide molecular b

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History and Epics in China and in the West aspects of all seven known KDM families are reviewed as well as our present knowledge of their involvement in cancers. Control of their aberrant behavior by design of chemical inhibitors, that have the potential to be powerful cancer fighting drugs, is an expanding human endeavor and is chronicled

Stress-Fracture

Yun Schüler-Zhou,Margot Schüller,Magnus Brodd by histone deacetylases. This chapter focuses on outlining representative histone acetyltransferases and their molecular mechanisms, to provide a picture of how their substrate-specificity is ensured. Next, how bromodomains recognize their target residues is presented. Finally, the molecular mecha

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