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Titlebook: DNA and Histone Methylation as Cancer Targets; Atsushi Kaneda,Yu-ichi Tsukada Book 2017 Springer International Publishing AG 2017 Demethyl

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发表于 2025-3-21 17:32:07 | 显示全部楼层 |阅读模式
书目名称DNA and Histone Methylation as Cancer Targets
编辑Atsushi Kaneda,Yu-ichi Tsukada
视频video
概述Describes the features of DNA and histone methylation associated with particular types of cancer.Compiles the current knowledge of the molecular basis of DNA and histone methylation and contextualizes
丛书名称Cancer Drug Discovery and Development
图书封面Titlebook: DNA and Histone Methylation as Cancer Targets;  Atsushi Kaneda,Yu-ichi Tsukada Book 2017 Springer International Publishing AG 2017 Demethyl
描述.This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets..
出版日期Book 2017
关键词Demethylation; DNA; Histone; Hypermethylation; Methylation
版次1
doihttps://doi.org/10.1007/978-3-319-59786-7
isbn_softcover978-3-319-86700-7
isbn_ebook978-3-319-59786-7Series ISSN 2196-9906 Series E-ISSN 2196-9914
issn_series 2196-9906
copyrightSpringer International Publishing AG 2017
The information of publication is updating

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The Molecular Basis of DNA Methylationand is crucial for development, especially in higher eukaryotes. Three DNA (cytosine-5)-methyltransferases, Dnmt1, Dnmt3a, and Dnmt3b, have been identified. Dnmt3a and Dnmt3b are mainly responsible for establishing DNA methylation patterns in the genome. Factors interacting with Dnmt3a or Dnmt3b, hi
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The Molecular Basis of DNA Demethylationng DNA methylation have been well characterized, those involved in demethylation have remained elusive until recently. Mounting evidence now suggests that the TET proteins, a family of AlkB-like Fe(II)/α-ketoglutarate-dependent dioxygenases, initiate active DNA demethylation by oxidizing 5-methylcyt
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Misregulation of Histone Methylation Regulators in Cancerl processes through divergent transcription activities. Recently, aberrant histone modifications have been shown to contribute significantly towards many diseases, notably cancer. Here, we summarize the known drivers leading to misregulation of DNA and histone methylation in cancer, and current ther
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DNA Methylation and Dysregulation of miRNA in Cancerthe expression of protein coding/noncoding RNAs by repressing translation or cleaving RNA transcripts in a sequence-depending manner. The unique characteristic function of miRNAs is to regulate RNA transcripts in human cells. Therefore, dysregulated expression of miRNAs can disrupt tightly regulated
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