Titlebook: DNA Topoisomerases and Cancer; Yves Pommier Book 2012 Springer Science+Business Media, LLC 2012 Tyrosyl-DNA-Phosphodiesterase.Ubiquitin.an

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Topoisomerase II Inhibitors: Chemical Biology, etoposide are FDA approved for the treatment of both leukemias and solid tumors. Most clinically active drugs targeting Top2 lead to elevated levels of covalent Top2-cleaved DNA complexes and exert their antitumor effect through enzyme-mediated DNA damage. Drugs targeting Top2 are accompanied by su

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Topoisomerase I Inhibitors: Current Use and Prospects,h other agents have ensured their clinical role. c has been part of drug regimens for ovarian cancer, small cell lung cancer (SCLC), and cancer of the uterine cervix; it has also been used as a radiosensitizer in non-small cell lung cancer (NSCLC). Irinotecan was the second drug with activity in col

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Topoisomerase II Inhibitors: Current Use and Prospects,because of their long successful track record, provide an element of comfort for treating physicians. Contained within this larger category are the epipodophyllotoxins (VP-16, or etoposide; and VM-26, or teniposide), anthracyclines (doxorubicin, or adriamycin; daunorubicin, or daunomycin; idarubicin

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Mechanisms Regulating Cellular Responses to DNA Topoisomerase I-Targeted Agents,nscription, and recombination. The enzyme clamps around duplex DNA and forms a transient 3′ phosphotyrosyl linkage with a single DNA end. This covalent intermediate is the cellular target of the camptothecin class of chemotherapeutics, which at clinically relevant concentrations induces DNA replicat

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