| 书目名称 | DNA Topoisomerases and Cancer |
| 编辑 | Yves Pommier |
| 视频video | |
| 概述 | Structure and mechanism of eukaryotic type IIA topoisomerases.DNA topoisomerase I and illegitimate recombination.Mechanism regulating cellular responses to DNA topoisomerase I-targeted agents |
| 丛书名称 | Cancer Drug Discovery and Development |
| 图书封面 |  |
| 描述 | .DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action.. |
| 出版日期 | Book 2012 |
| 关键词 | Tyrosyl-DNA-Phosphodiesterase; Ubiquitin; antigens; camptothecins; transcriptional stress |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4614-0323-4 |
| isbn_softcover | 978-1-4614-2963-0 |
| isbn_ebook | 978-1-4614-0323-4Series ISSN 2196-9906 Series E-ISSN 2196-9914 |
| issn_series | 2196-9906 |
| copyright | Springer Science+Business Media, LLC 2012 |
发表于 2025-3-21 18:46:31
