Titlebook: DNA Synthesis; Present and Future Ian Molineux,Masamichi Kohiyama Book 1978 Springer Science+Business Media New York 1978 DNA.Mammalia.deve

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https://doi.org/10.1007/978-3-030-19823-7autoradiographic techniques to examine labeled metaphase chromosomes. His work, and that of Hsu (1964), demonstrated that DNA replication is initiated at multiple sites along the chromosome and that each chromosome shows a reproducible, characteristic pattern of replication in different stages of S

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Christian Oliva,Luis F. Lago-Fernándezl cells (3). In humans, ara-c has been quite effective in the treatment of acute granulocytic leukemia (4,5). Two of the possible hypotheses for its inhibitory effect on DNA synthesis center on the replicative DNA polymerase. In the first model, the triphosphate form of ara-C inhibits competitively

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Yu-Shan Tai,Yi-Ta Chen,(Andy) An-Yeu WuA biochemical approach of the initiation step of chromosomal replication in . will very probably require the isolation of DNA sequences enriched in the unique site where initiation occurs, ..

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Yu-Shan Tai,Yi-Ta Chen,(Andy) An-Yeu WuThe initiation of chromosomal replication is the initial event in the bacterial cell cycle and all subsequent steps occur at a specific time after initiation. Thus the frequency of initiation determines the overall rate of DNA synthesis per cell, the amount of DNA per cell, and the rate of cell division (1).

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