Titlebook: DNA Replication, Recombination, and Repair; Molecular Mechanisms Fumio Hanaoka,Kaoru Sugasawa Book 2016 Springer Japan KK 2016 DNA replicat

staging

DNA Replication Timing: Temporal and Spatial Regulation of Eukaryotic DNA Replicationof these origins is regulated by .-acting sequences and factors that may interact with them. Competition for limiting initiation factors also could regulate the order of origin firing in yeasts. In higher eukaryotes, replication timing may be regulated on a larger genome scale. These so-called repli

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Regulation of Recombination by Chromatin influences on DNA and its metabolism. Due to its compactness, chromatin generally represses all DNA-templated reactions by preventing DNA-processing proteins from accessing to and/or functioning at their target sites. On the contrary, there are many cases in which condensed chromatin rather facilit

infelicitous

Homologous Recombination During Meiosisand repair of developmentally programmed DNA double-strand breaks (DSBs). Cytotoxic lesions such as DSBs are hazardous, potentially mutagenic events that can compromise cellular function. However, during meiosis DSBs are required to establish physical connections between homologous maternal and pate

recede

DNA Damage Recognition and Repair in Mammalian Global Genome Nucleotide Excision Repairdehyde metabolites or environmental genotoxins such as radiation and chemicals. Unrepaired DNA damage interferes with essential DNA transactions, such as replication and transcription, and eventually gives rise to the alteration of genetic information. Because genomic instability can cause cell deat