Titlebook: DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells; Muriel W. Lambert,Jacques Laval Book 1989 Springer Science+Bus

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Molecular Analysis of Mutations at the HPRT Locus: UV Mutation Spectra in Normal and UV-Sensitive V7gle and tandem double base pair substitutions with no preference for a particular type of change, although the GC ⇒ CG transversion was not detected. Mutations in V-H1 cells consisted of single and tandem double base pair changes, which were all GC ⇒ AT transitions, and frame shift mutations. The as

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Comparison of the Mutational Specificities Exhibited by BPDE in , and CHO Cells)anti = (+/−)., and remarkably the reverse is seen at the crpt locus in TA100 bacteria (−) anti = (+/−) syn > ( + ) . (Stevens, ., 1985). It is also known that the ( + ) . enantiomer is more than 60 fold more active as a tumor initiator in CD-1 and Sencar mice (Pelling, ., 1984).

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The Roles of Beta- and Delta-Eliminations in the Repair of AP Sites in DNAhe AP site. Since in each phosphodiester bond, there are two linkages, C.-O-P and C.-O-P, that can be hydrolyzed, four different hydrolases might participate in the excision of AP sites. In fact, we know a single class of AP endonucleases; these enzymes hydrolyze the C.-O-P bond 5′ to AP sites and t