Titlebook: DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells; Muriel W. Lambert,Jacques Laval Book 1989 Springer Science+Bus

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https://doi.org/10.1007/978-3-030-21828-7formation of various alkylated bases in DNA. More than ten kinds of methylated bases are produced by the treatment of cells with a simple methylating agent, such as N-methyl-N-nitrosourea (MNU) and N-methyl-N′-nitro-N-nitrosoguanidine (MNNG).

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https://doi.org/10.1007/978-3-319-00801-1tive damage to DNA (both base and sugar damage). Yet, the nature and relative rates of the reactions involving active oxygen species make it difficult to ascertain, in each particular situation, what reactants may act as the predominant genotoxicant and what DNA repair mechanisms may ensue.

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Book 1989 of organisms in some respects yet are strikingly different from them in others. Within the past decade there have been a number of international conferences on DNA damage and repair mechanisms but none has been focused on these processes in mammalian cells.

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her groups of organisms in some respects yet are strikingly different from them in others. Within the past decade there have been a number of international conferences on DNA damage and repair mechanisms but none has been focused on these processes in mammalian cells.978-1-4684-1329-8978-1-4684-1327-4

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Anne Laure Bandle,Raphael Conteln be either mutagenic or lethal. Most recently, in order to separate the potential biological effects of each derivative, defined oligonucleotide sequences containing a single adduct have been synthesized and used to study both replication and mutation. These defined oligomers have also been of grea

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Women, Subject Choice and Employment,lecular weight of 3 0.2 Kd. The protein was purified to apparent homogeneity and exhibited two different enzymatic activities: a DNA glycosylase and an activity incising DNA at apurinic/ apyrimidinic (AP) sites. Moreover, based on restriction maps, the . gene is not associated with known . genes cod

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Cyber-Salvation: Body in Virtual Skies MNNG or nitrosoureas (Day, ., 1980a,b; Erickson, 1980a,b; Scudiero, ., 1984 a,b; Gibson, ., 1986). The results obtained in cell culture are clear-cut; for example, with MNNG as the damaging agent, the inactivation slopes of survival curves of Mer. cells are up to 50 fold steeper than are those of M

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Ove Jakobsen,Vivi M. L. Storslettenr εCdR. Molar ratios of oxetG/εCdR and oxetG/εAdR in DNA were about 3 0 and 80, respectively, in these three organs. In contrast, εAdR and εCdR were not detected (detection limit, 2 5 fmoles/mg DNA) in the kidney of group I nor in the liver from group II rats. These findings are discussed in relatio

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Luk Bouckaert,Knut J. Ims,Peter Ronaon analyses supplied support for the idea that proneness to mutation is passed on to daughter cells (Maher, ., 1988). As another parallel between bacteria and mammalian cells DNA damage causes reinitiation of replication (Kogoma, ., 1979) which in mammalian cells is observed as gene amplification (L