Titlebook: DNA Recombination; Methods and Protocol Hideo Tsubouchi Book 2011 Springer Science+Business Media, LLC 2011 DNA double-strand break.DNA mic

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Methods in Molecular Biologyhttp://image.papertrans.cn/d/image/260174.jpg

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DNA Recombination978-1-61779-129-1Series ISSN 1064-3745 Series E-ISSN 1940-6029

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The Journey of Arsenic from Soil to Planteave recombinogenic substrates such as single-stranded DNA gaps. Other types of damages result in general genome instability such as chromosome loss, chromosome fragmentation, and chromosome rearrangements. The genome is kept intact through recombination, repair, replication, checkpoints, and chromo

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https://doi.org/10.1007/978-3-030-61006-7nd breaks (DSBs) by a conserved meiosis-specific protein, Spo11. Meiotic DSBs are not formed at random along chromosomes but are formed in clusters known as recombination hot spots. To understand the regulation of this initiation step of meiotic recombination, determining the timing and location of

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https://doi.org/10.1007/978-3-030-61006-7ome segregation in most eukaryotes. This chapter describes a straightforward microarray-based approach to measure the genome-wide distribution of meiotic DSBs by detecting the single-stranded DNA (ssDNA) that transiently accumulates at DSB sites during recombination. The protocol outlined here has b

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https://doi.org/10.1007/978-3-030-61006-7 DNA break, the topoisomerase remains covalently linked to the DNA and removes itself when the break is re-ligated. While the lifetime of a covalent topoisomerase–DNA complex is usually short, several clinically important cancer drugs kill cancer cells by inhibiting the removal of covalently linked

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https://doi.org/10.1007/978-3-030-61006-7genomes of eukaryotes. DSBs form normally during a variety of biological processes, such as V–D–J recombination and yeast mating type switching, but unprogrammed DSBs are among the most dangerous types of lesion because if left unrepaired they can lead to loss of genetic material or chromosomal rear

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The Police Investigation of Art Fraudrmed via several branched intermediates, including single end invasions and double Holliday junctions. Two-dimensional gel electrophoresis provides a sensitive and specific approach for detecting branched recombination intermediates, determining their genetic requirements, and enriching intermediate