Titlebook: DNA Damage and Repair in Human Tissues; Betsy M. Sutherland,Avril D. Woodhead Book 1990 Plenum Press, New York 1990 DNA.Laboratory.Xeroder

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The Significance of DNA Damage and Repair Mechanisms in Health Risk Assessmentred (Bohr and Wassermann, 1988). It is not our intent to discuss the advances made in the field of DNA damage and repair, but rather to provide a conceptual outline for considering how such information may be applicable or relevant to the assessment of health risks, particularly those posed by exposure to carcinogens and mutagens.

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integrity of human populations. Although studies on isolated DNA in vitro, on prokaryotes, on mammalian cells in culture, and on laboratory animals have provided essential background information, it is now possible to study DNA damage and repair in human tissues directly. New techniques of high sens

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Measurement of DNA Adducts by Immunoassaysntually demonstrate the dose received and/or allow the prediction of cancer risk. At the present time evidence that the occurrence of certain adducts is associated with specific chemical exposures is accumulating, and multiple methods are being validated to confirm these observations.

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