Titlebook: DNA Damage and Repair; Volume 2: DNA Repair Jac A. Nickoloff,Merl F. Hoekstra Book 1998 Springer Science+Business Media New York 1998 Activ

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https://doi.org/10.1007/978-3-319-31400-6nd . were shown to possess a postreplicative mismatch correction system whose function involved the resynthesis of long tracts of DNA, up to several kilobases in length .. In addition, . was shown by Lieb . to possess an additional, very short-patch (VSP) mismatch repair pathway, which is dedicated

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The Pottery Pathway at the Ceremonial CenterNA, damaged DNA sites must be repaired, and organisms have several DNA repair pathways that are vital in maintaining genome stability. Each individual DNA repair pathway (i.e., error-free repair, base excision repair, nucleotide excision repair, and so forth) is generally similar throughout nature,

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Augusto S. Auler,Luís Beethoven Pilóent, such as ionizing radiation, or as a consequence of DNA repair proteins recognizing and excising DNA damage. Thus, the majority of DNA repair mechanisms, including recombinational repair pathways, share a common essential step, phosphodiester bond formation, that restores the integrity of the DN

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https://doi.org/10.1007/978-3-319-21885-4 living cells. IR causes a spectrum of DNA lesions .,including DNA single-strand breaks (SSBs), double-strand breaks (DSBs), DNA—protein crosslinks (intra- and interstrand), and apurinic/apyrimidinic sites (. Chapter 5). The extent of DSBs correlates well with lethality following IR .. IR also damag

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https://doi.org/10.1007/978-3-319-21885-4mes, cell death, or cancer. Eukaryotic cells have evolved specific mechanisms for repairing DSBs by either homologous recombination (HR) or nonhomologous recombination (NHR) pathways. This chapter will summarize recent progress in understanding these pathways in eukaryotes. Of particular interest is

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