Titlebook: DNA Damage and Repair; Volume 2: DNA Repair Jac A. Nickoloff,Merl F. Hoekstra Book 1998 Springer Science+Business Media New York 1998 Activ

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Cellular Functions of Mammalian DNA Ligases,ent, such as ionizing radiation, or as a consequence of DNA repair proteins recognizing and excising DNA damage. Thus, the majority of DNA repair mechanisms, including recombinational repair pathways, share a common essential step, phosphodiester bond formation, that restores the integrity of the DN

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Modulations in Chromatin Structure During DNA Damage Formation and DNA Repair, dynamic structure of chromatin. Understanding the modulation of DNA damage and repair in chromatin, as well as the modulation of chromatin structure by DNA damage and its repair processing, is necessary for understanding the fate of potential mutagenic and carcinogenic lesions in DNA. The central i

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Transcriptional Responses to Damage Created by Ionizing Radiation, living cells. IR causes a spectrum of DNA lesions .,including DNA single-strand breaks (SSBs), double-strand breaks (DSBs), DNA—protein crosslinks (intra- and interstrand), and apurinic/apyrimidinic sites (. Chapter 5). The extent of DSBs correlates well with lethality following IR .. IR also damag

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Posttranslational Mechanisms Leading to Mammalian Gene Activation in Response to Genotoxic Stress,lar responses occur in unicellular (. Chapters 7 and 18 in vol. 1) and multicellular eukaryotes. In mammalian cells, changes in gene expression are initiated and signaled primarily through posttranslational modifications of key regulatory molecules. Almost immediately on exposing cells to genotoxic

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Mechanisms for DNA Double-Strand Break Repair in Eukaryotes,mes, cell death, or cancer. Eukaryotic cells have evolved specific mechanisms for repairing DSBs by either homologous recombination (HR) or nonhomologous recombination (NHR) pathways. This chapter will summarize recent progress in understanding these pathways in eukaryotes. Of particular interest is

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Cellular Functions of Mammalian DNA Ligases,anisms, including recombinational repair pathways, share a common essential step, phosphodiester bond formation, that restores the integrity of the DNA substrate molecule(s). In addition, DNA-joining events are required to link together the Okazaki fragments generated during lagging strand DNA synthesis.

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Mechanisms for DNA Double-Strand Break Repair in Eukaryotes,ous recombination (NHR) pathways. This chapter will summarize recent progress in understanding these pathways in eukaryotes. Of particular interest is the surprising discovery that the nonhomologous pathway shares at least four gene products with V(D)J recombination, a site-specific recombination pathway that generates immunological diversity.

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coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.978-1-4757-5015-7978-1-59259-455-9