Titlebook: DJ-1/PARK7 Protein; Parkinson’s Disease, Hiroyoshi Ariga,Sanae‘M. M. Iguchi-Ariga Book 2017 Springer Nature Singapore Pte Ltd. 2017 DJ-1.Pa

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https://doi.org/10.1007/1-4020-5368-1egulation, inflammatory and fibrogenic niche formation, and glycation damage prevention. Although a disease-associated genetic study within the past decade has demonstrated that the mutation of DJ-1 is associated with autosomal early-onset Parkinson’s disease, increasing evidence suggests that DJ-1

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Structural Biology of the DJ-1 Superfamily,nt in most organisms. Many of these proteins remain poorly characterized at the biochemical level, but include some known chaperones, proteases, and various stress response proteins that remain mechanistically mysterious. This chapter outlines what is known from a structural perspective about the ce

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Expression of DJ-1 in Neurodegenerative Disorders, a conserved protein termed DJ-1. DJ-1 is a ubiquitous protein, and within the brain, it is present in the nucleus and cytoplasm of both neuronal and glial cells. DJ-1 is a multifunctional protein, and numerous studies have ascribed various roles, including antioxidative properties, chaperone functi

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The Multifaceted Roles of DJ-1 as an Antioxidant,cysteine residues, which are involved in its dimerisation and functional properties. A mildly oxidised form of DJ-1 is the most active form and protects cells from oxidative stress conditions. DJ-1 functions as an antioxidant through a variety of mechanisms, including a weak direct antioxidant activ

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Regulation of Signal Transduction by DJ-1,ptosis, and autophagy to adapt to changing environmental stimuli and stresses. Perturbations of DJ-1 levels or function can disrupt the equilibrium of homeostatic signaling networks and set off cascades that play a role in the pathogenesis of conditions such as cancer and Parkinson’s disease..DJ-1 p