Titlebook: D-Amino Acids; Physiology, Metaboli Tohru Yoshimura,Toru Nishikawa,Hiroshi Homma Book 2016 Springer Japan 2016 D-Serine.D-Aspartate.Brain f

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Abnormal ,-Serine Metabolism in Amyotrophic Lateral Sclerosiso reported in a few patients with sporadic ALS or familial ALS with A4T-SOD1. The .serine accumulation in the mouse model is explained by a combination of increased .serine-producing enzyme and decreased .serine-degrading enzyme, .amino acid oxidase (DAO), which are both found in activated glial cel

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Endocrine Activity of ,-Aspartate in Nonmammalian Animalsdentification of its occurrence in reproductive cells and organs of vertebrates highlights the key role played by these endogenous compounds along the evolutionary axis. In this review we have summarized the current knowledge of the main actions of .aspartate on female and male reproductive processe

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Free ,-Aspartate in Nonmammalian Animals: Detection, Localization, Metabolism, and Functionnzymatic catabolism. A variety of biological models, each having distinct anatomies, morphologies, biochemistries, and behaviors, have been used to investigate the fundamental mechanisms of .-Asp involvement in the normal and pathological functioning of cells and organisms. Many physiological and be

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-Amino Acid Residues in Proteins Related to Aging and Age-Related Diseases and a New Analysis of ths racemization of the Asp residues. The racemization of Asp residues in proteins does not occur uniformly but does so at specific residues on the basis of the sequence context or structural considerations. Therefore, it is necessary to determine the nature of Asp residues at specific sites within pa

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Mrudula Sarvabhatla,Chandra Sekhar Voruguntiuggested to be an endogenous ligand for the δ-type glutamate receptor in the cerebellum. These interactions have been considered to play a pivotal role in the regulation of the higher-order brain functions because glutamate neurotransmission is essential for their expression and control. The first h

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https://doi.org/10.1007/978-981-19-6032-1 of synaptic plasticity underlying cerebellar motor learning. In the developing cerebellum, we found that .Ser, released from Bergmann glia in response to neuronal activity, binds to δ2 receptors, thereby conveying a critical signal for LTD and motor learning. Interestingly, while .Ser activates NMD

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Lecture Notes in Mechanical Engineeringorebrain areas, the NMDAR function levels are under control of the extracellular .serine concentrations that are regulated in a different manner from that of classical neurotransmitters by neuronal and glial activities, the calcium-permeable AMPA receptor, the Asc-1 neutral amino acid transporter, a