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Titlebook: D-Amino Acids; Physiology, Metaboli Tohru Yoshimura,Toru Nishikawa,Hiroshi Homma Book 2016 Springer Japan 2016 D-Serine.D-Aspartate.Brain f

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发表于 2025-3-21 19:01:42 | 显示全部楼层 |阅读模式
书目名称D-Amino Acids
副标题Physiology, Metaboli
编辑Tohru Yoshimura,Toru Nishikawa,Hiroshi Homma
视频video
概述Describes functions of ?-amino acids comprehensively.Chapters are organically arranged for readers’ clearer understanding.Written by the world’s leading scientists in the field
图书封面Titlebook: D-Amino Acids; Physiology, Metaboli Tohru Yoshimura,Toru Nishikawa,Hiroshi Homma Book 2016 Springer Japan 2016 D-Serine.D-Aspartate.Brain f
描述.This book presents a comprehensive overview of the roles of ᴅ-amino acids and latest research findings, to reveal their fascinating aspects and to facilitate better understanding of their important roles in physiology and diseases. It also provides useful hints for the development of drugs and functional foods. ᴅ-Amino acids were once called unnatural amino acids and were considered to be insignificant for eukaryotes especially in mammals. However, different ᴅ-amino acids have been revealed to be distributed in various mammalian tissues and to bear important physiological roles. For example, ᴅ-serine is implicated in memory formation and learning, and its abnormal concentration in tissues have been reported in neurological diseases such as schizophrenia and amyotrophic lateral sclerosis. ᴅ-Aspartate is found in a variety of mammalian tissues, particularly in the central nervous system and the genitals. ᴅ-Aspartate facilitates the endocrine secretion of prolactin, inhibits the secretion of melatonin, and plays a peculiar role in the control of reproductive functions in mammals, including the stimulation of testosterone synthesis. Written by the leading scientists in the field, this
出版日期Book 2016
关键词D-Serine; D-Aspartate; Brain function; Schizophrenia; Amyotrophic lateral sclerosis (ALS); N-methyl-D-asp
版次1
doihttps://doi.org/10.1007/978-4-431-56077-7
isbn_softcover978-4-431-56772-1
isbn_ebook978-4-431-56077-7
copyrightSpringer Japan 2016
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Overviewp has become a milestone opening a new avenue in the research fields of not only .amino acids but also the glutamate neurotransmission. This chapter consists of an overview and seven review articles describing the following current extension of our knowledge on different aspects of physiological fun
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Physiological Functions of ,Serine Mediated Through δ2 Glutamate Receptors in the Cerebellumr) which regulates synaptic plasticity underlying certain types of learning and memory in the central nervous system. While .Ser is abundant in the forebrain throughout life, it exists only transiently in the immature cerebellum because .amino acid oxidase (DAAO), a .Ser-degrading enzyme, begins to
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Serine and the Pathophysiology of Schizophreniahdrawal and anhedonia. Pathologic changes in the brain include cortical atrophy, loss of pyramidal cell dendritic complexity and spine density, ventricular enlargement, and reduction in intracellular mediators of neuronal plasticity. Acute blockade of N-methyl-.aspartate receptors (NMDARs) with keta
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Serine Racemase Knockout Mice: Neurotoxicity, Epilepsy, and Schizophreniaceptor (NMDAR). The synthesis of .serine from .-serine is catalyzed by serine racemase (SR). To date, several SR knockout (KO) mouse strains have been established to elucidate the role of the SR-.serine pathway in the regulation of NMDAR activity under both physiological and pathological conditions.
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