Titlebook: Cytokines and Growth Factors in Blood Transfusion; Proceedings of the T Cees Th. Smit Sibinga (Initiator and Organiser),P. Conference proce

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The Role of the Common Gamma Chain of the IL-2, IL-4, IL-7 and IL-15 Receptors in Development of Lymot essential for T cell development, it was suspected that this component of the IL-2R was also part of receptors for other cytokines. This suspicion was confirmed soon thereafter when it was found that the IL-2Rγ chain is also a component of the receptors of IL-4, IL-7, IL-9 and IL-15 [5–7]. Theref

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Signal Transduction from the Haematopoietic Growth Factor ReceptorsThis concise overview will start with an introduction to the basic principles of HGF-R signaling. Subsequently, a selection of the recent results obtained in this dynamic area of research, and their implications for our insights in the regulation of normal haematopoietic cell development as well as

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Ex Vivo Cytokine Production in Blood Components: Relevant or Irrelevant of high levels of cytokines, exhibiting . pyrogenic activity in stored platelets [5]. Evidence is growing that transfusion of platelet concentrates containing high amounts of these cytokines may cause transfusion reactions [5–7]. The clinical relevance of cytokines in transfusion products will be d

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Haematopoietic Growth Factors for the Expansion of Peripheral Blood Progenitor Cellsd tumours and haematologic malignancies. As compared with rescue by autologous bone marrow cells, restoration with peripheral blood progenitor cells (PBPC) shortens the period of pancytopenia post transplantation and reduces the risk of infection and bleeding.

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Peripheral Blood Progenitor Grafts Obtained from Healthy Donorse use of mobilized PBPC instead of BM as source of allogeneic stem cells has rapidly expanded [3]. The present article will elucidate the potential benefits and limitations of allogeneic PBPC with particular focus on collection and cellular composition of PBPC grafts obtained from healthy donors.

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