Titlebook: Cytokine Storm Syndrome; Randy Q. Cron,Edward M. Behrens Book 2024Latest edition The Editor(s) (if applicable) and The Author(s), under ex

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Criteria for Cytokine Storm Syndromesto an evolution of the concept of a “cytokine storm.” Emerging and unsolved challenges in the diagnosis of the different forms of CSSs highlight the need for diagnostic tools and well-established classification criteria to enable timely recognition and correct classification of patients.

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Genetics of Acquired Cytokine Storm Syndromesble genetic background. Rather than a simple, binary definition of pHLH and sHLH, HLH represents a spectrum of diseases, from a severe complication of common infections (EBV, influenza) to early onset familial diseases that can only be cured by transplantation.

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Genetics of Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritissible for the frequently fatal multiorgan system failure seen in MAS. Whole exome sequencing as well as targeted sequencing of pHLH-associated genes in patients with SJIA-associated MAS demonstrated increased “burden” of rare protein-altering variants affecting the cytolytic pathway compared to heal

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CD8+ T Cell Biology in Cytokine Storm Syndromesr cytokine release syndromes (CSS). Moreover, we review the molecular mechanisms underpinning CD8. T cell-mediated lymphocyte cytotoxicity, key to the development of familial HLH. Together, recent insights to the pathophysiology of CSS in general and HLH in particular are providing promising new the

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0065-2598 ntations, risk factors and treatment. New-to-this-edition features include dedicated chapters on severe COVID-19 CSS, and post-COVID CSS of multi-system inflammatory syndrome in children (MIS-C). In addition, n978-3-031-59817-3978-3-031-59815-9Series ISSN 0065-2598 Series E-ISSN 2214-8019

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Book 2024Latest editions of the disorder, from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors and treatment. New-to-this-edition features include dedicated chapters on severe COVID-19 CSS, and post-COVID CSS of multi-system inflammatory syndrome in children (MIS-C). In addition, n

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https://doi.org/10.1057/9780230505698to an evolution of the concept of a “cytokine storm.” Emerging and unsolved challenges in the diagnosis of the different forms of CSSs highlight the need for diagnostic tools and well-established classification criteria to enable timely recognition and correct classification of patients.