Titlebook: Cytokine Frontiers; Regulation of Immune Takayuki Yoshimoto,Tomohiro Yoshimoto Book 2014 Springer Japan 2014 Anti-inflammatory cytokines.Pr

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The Global and Regional Climate System molecular structures, receptor structures, and signal transduction pathways. Each cytokine, however, acts on distinct types of cells that express their specific receptor. The functional IL-18 receptor is specifically induced by cytokines such as IL-2 and IL-12. During innate immune responses, IL-1β

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https://doi.org/10.1007/978-3-540-38819-7ral to the pathogenesis of many immune-mediated inflammatory disorders and was shown to act via a novel IL-17-producing T helper subset, the Th17 cell. Many innate cells also respond to IL-23 and are important in both resistance to infection and in mediating autoimmune pathology. These cells are cha

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G. Sundström,Å Larsson,M. Tarkpeaby epithelial tissues. Similar to other IL-1 family cytokines, they promote inflammatory responses by activating kinases such as JNK, p38, and the IKKs, and activating transcription factors such as NFκB. They only do this, however, after N-terminal processing, which increases their specific activity

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R. F. Addison,A. B. McKague,C. C. Waldendisease tissue in rheumatoid arthritis and on exploring the dysregulation of cytokine expression within that tissue..From those first successful clinical trials we conducted in 1992 with infliximab, which were widely publicized more than a year before publication, a competition emerged between a set

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https://doi.org/10.1007/978-3-540-38522-6it has been demonstrated that IL-25 (IL-17E) is involved in the initiation and amplification of type 2 immune responses. Recent studies have shown that a number of cell types including activated Th2 cells, epithelial cells, mast cells, eosinophils, and macrophages produce IL-25 in response to a vari

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R. Anliker,G. C. Butler,V. Zitkoere it acts as an alarmin by binding to the receptor ST2. The receptor ST2 is widely expressed in the human body, and IL-33 exerts a wide range of biological activities depending on the target cells and cellular context. IL-33 is essential for host protection from helminth infections by promoting ty

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Lóránt Dávid,Zoltán Ilyés,Zoltán Barosh hematopoietic and nonhematopoietic cell lineages, including dendritic cells (DCs), basophils, eosinophils, mast cells, CD4., CD8., and natural killer (NK) T cells, B cells, and epithelial cells. Although the role of TSLP in the promotion of TH2 responses has been extensively studied in the context

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Lóránt Dávid,Zoltán Ilyés,Zoltán Barosic cells, B cells, and T cells. A major role of IL-10 is to act as a feedback regulator of the immune response by inhibiting the production of inflammatory cytokines by innate cells such as macrophages and dendritic cells. Thus, the production of IL-10 in response to microbial flora is required to i