Titlebook: Cytochrome P450 Protocols; Ian R. Phillips,Elizabeth A. Shephard Book 19981st edition Springer Science+Business Media New York 1998

不容置疑

Spectrofluorometric Analysis of CYP2A6-Catalyzed Coumarin 7-Hydroxylation,otal hepatic P450 content) (.), although substantial intermdividual variation exists (.–.). This P450 is primarily a hepatic protein, as suggested by its absence from several extrahepatic tissues, including adult human lung, colon, breast, kidney, and placenta microsomes (.). According to experiment

JEER

忍耐

,High-Performance Liquid Chromatographic Analysis of CYP2CSCatalyzed Paclitaxel 6α-Hydroxylation, content (.) and a blmodal dlstrlbutlon in CYP2C8 protein amounts m a panel of human liver mlcrosomes has been reported (.). Experiments with primary cultures of human hepatocytes have indicated that CYP2C8 is subject to inductton by phenobarbital, dexamethasone, and rifampin (rifampicm) (.). Little

excrete

Harridan

filial

Gerontology

Capitulate

相互影响

Anhydrous

1064-3745 estigation of cytochromes P450. Described in detail by hands-on experimentalists for easy reproducibility, these methods include spectral analysis, purification and enzymatic assays, expression in heterologous systems, and the production and use of antibodies, as well as methods for quantification o